Preparation of Acellularized Bone Using Ultra High Pressure Technology for Tissue Engineering
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چکیده
One of key factors affecting the effective application of tissue engineering is the development of scaffolds, which provide the physical support for adhesion and expansion of cells that can regenerate the lost of diseased tissue. Recently, several scaffolds consisting of synthetic materials or substance derived from natural tissue, such as poly(lactic acid) (PLA) (1), poly(glycolic acid) (PGA) (2), hyaluronic acid (3) and collagen (4), have been mainly studied. They have been able to form various structures, such as porous, fibrous and gel to be adapted to the objective tissue. It was reported that the shape and microscopic structure of them act an important role in tissue formation as well as the physical and physicochemical nature of scaffold (5). However, it is difficult to actualize the same shape and structure as the biological tissue.
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تاریخ انتشار 2006